Ibopamine Eye Drops In Ophthalmology
نویسندگان
چکیده
Ibopamine eyedrops are used in ophthalmology. This molecule is characterized by a dual mechanism of action, since it acts on both adrenergic and dopaminergic receptors. The adrenergic action is responsible for a marked mydriasis without accommodative paralysis, while the dopaminergic action promotes the production of aqueous humor. Given this dual action, ibopamine may be useful for diagnostic purposes in ophthalmology. This review article aims at presenting the most intriguing evidence on ibopamine and discusses the profile of patients who may be best suitable to this molecule. Key-words: Glaucoma, ibopamine, provocative test, safety mydriasis.
منابع مشابه
The effects of 2% ibopamine eye drops on the intraocular pressure and pupil motility of patients with open-angle glaucoma.
PURPOSE Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its alpha-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders. METHODS This is a randomized, crossover, open-labeled, two- center study. Forty patients (20 open-angle glaucoma patients and 20...
متن کاملUse of ibopamine eye drops in Ophthalmology
Ibopamine eye drops are used in Ophthalmology. This molecule is characterized by a dual mechanism of action, since it acts on both adrenergic and dopaminergic receptors. The adrenergic action is responsible for a marked mydriasis without accommodative paralysis, while the dopaminergic action promotes the production of aqueous humor. Given this dual action, ibopamine may be useful for diagnostic...
متن کاملEffects of ibopamine eye drops on intraocular pressure and aqueous humor flow in healthy volunteers and patients with open-angle glaucoma.
PURPOSE On the basis of intraocular pressure measurements and fluorophotometry we assessed the effects of 2% ibopamine eye drops on aqueous humor production in normal and glaucomatous eyes. METHODS Thirty subjects (15 healthy volunteers and 15 open-angle glaucoma patients with ocular hypertension) were included in a placebo-controlled study with random assignment of treatment from masked cont...
متن کاملIbopamine treatment in chronic hypotony secondary to long-lasting uveitis. A case report.
PURPOSE To assess the clinical efficacy of ibopamine eye drops in severe hypotony secondary to chronic progressive uveitis. METHODS Case report. A 47-year-old man with a 37-year history of diffuse uveitis and severe refractory hypotony was treated with topical 2% ibopamine (Trazyl) six times a day. Intraocular pressure, visual acuity, visual field and side effects were recorded during 15 mont...
متن کاملComparison between the 1% and 2% ibopamine provocative test in primary open-angle glaucoma patients: sensitivity, specificity and tolerability.
PURPOSE To compare intraocular pressure (IOP) rise in normal individuals and primary open-angle glaucoma patients and the safety and efficacy of ibopamine eye drops in different concentrations as a provocative test for glaucoma. METHODS Glaucoma patients underwent (same eye) the ibopamine provocative test with two concentrations, 1% and 2%, in a random sequence at least 3 weeks apart, but not...
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